Antiviral T cell responses
نویسندگان
چکیده
Around 700 BCE, a new military formation called the phalanx was established in ancient Greece: a tight column of heavy infantry carrying long spears, or pikes, used in a single prong of attack. Later, in the battle of Marathon described by Herodotus, the Greeks learned the advantages of multipronged attacks, a strategy still used in modern warfare. Is the immune system similar in its approach to combatting pathogens or tumors?
منابع مشابه
Brief Report IMMUNOBIOLOGY CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus
The generation of antigen-specific CD8 T-cell responses is integral to effective cell-mediated antiviral immunity. Indeed, the control of infections with many viral pathogens is highly dependent on the timely and successful priming of naive T cells by professional antigen-presenting cells (APCs). It has been widely reported, and is now generally accepted, that cross-presentation, namely the acq...
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Polyomavirus (PyV) infection induces protective T cell-independent (TI) IgM and IgG antibody responses in T cell-deficient mice, but these responses are not generated by immunization with viral proteins or virus like particles. We hypothesized that innate signals contribute to the generation of isotype-switched antiviral antibody responses. We studied the role of complement receptor (CR2) engag...
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Although many studies have investigated the requirement for CD4(+) T cell help for CD8(+) T cell responses to acute viral infections that are fully resolved, less is known about the role of CD4(+) T cells in maintaining ongoing CD8(+) T cell responses to persistently infecting viruses. Using mouse polyoma virus (PyV), we asked whether CD4(+) T cell help is required to maintain antiviral CD8(+) ...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 201 شماره
صفحات -
تاریخ انتشار 2005